1, absorption of intestinal toxic substances, such as phenol, tyramine benzene ethylenediamine, etc. from the intestine into the blood, due to kidney failure and liver detoxification function is reduced, toxic substances in the blood accumulation and cause poisoning. 2, due to kidney failure, urea into the intestinal cavity, through the intestinal bacteria decomposition into ammonia and ammonium salts, and then absorbed into the blood, causing symptoms of neurological toxicity. 3, certain protein decomposition toxic products, such as guanidine compounds accumulation, can inhibit The accumulation of certain toxic products of protein decomposition, such as guanidine compounds, can inhibit the activity of certain enzymes (lactate dehydrogenase, ATPase, etc.) in the body, resulting in convulsions in the affected dog, and can also induce gastroenteritis, pericarditis, bleeding and reduced immune function in dogs. 4. Acidosis occurs due to impaired excretion of acidic metabolites, causing changes in respiration, cardiovascular activity and coma, etc.
