When to Vaccinate Puppies At 2 months of age, puppies can receive multiple vaccinations to effectively prevent infectious diseases such as canine distemper. Rabies vaccination is mandatory at three months of age to prevent the dog from carrying the rabies virus. Puppy vaccinations generally require multiple vaccinations to ensure the integrity of the immune system. Dogs must be vaccinated. Distemper is an infectious disease that dogs can easily get when they are young and has a very high fatality rate. Multiple vaccines can help form antibodies in the dog’s body to defend against a range of infectious diseases such as distemper, and three multiple vaccinations are generally required at a young age to truly develop a complete immune system.
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